The overall expression of RASSF1A in 38 primary NPC tumors was down-regulated compared to that of 14 normal nasopharyngeal epithelial biopsies (p < 0.01), and with completely silenced of RASSF1A expression in 2 cases of primary NPC tumors (Figure 1). The gene discussed is RASSF1; the disease is nasopharyngeal carcinoma.