RASSF1 and nasopharyngeal carcinoma: A numer of tumor suppressor genes have been implicated to harbor promoter methylation at CpG islands in NPC, such as RASSF1A (Ras association domain family 1 isoform A), p16, BLU [7,8] and recently LARS2 (leucyl-tRNA synthetase 2, mitochondrial) was found to involve in this process[9].