For instance rs2076530 (A/G), a single nucleotide polymorphism (SNP) in BTNL2 (butyrophilin-like 2, a MHC class II associated gene), has been shown to be strongly associated with several autoimmune diseases such as MS, RA, T1D, sarcoidosis and systemic lupus erythematosus (SLE) [7]–[12]. The gene discussed is BTNL2; the disease is autoimmune disease.