HERC2 and Angelman syndrome: In humans, the HERC2 genomic locus, including several partially duplicated paralogs (duplicons) of HERC2[27],[28], corresponds to the chromosomal breakpoint region in deletions that cause the Prader-Willi and Angelman syndromes [29],[30] although lack of HERC2 protein does not seem to play a role in these syndromes [6].