According to the data presented in Figure 4, which demonstrate that severe proteinuria is inversely correlated with Dnase1 mRNA levels and enzyme activities, and positively with EDS in GBM, it was important to analyse whether low Dnase1 mRNA levels also correlated with EDS deposition in the mesangial matrix, or only in GBM. This evidence concerns the gene DNASE1 and glioblastoma.