As a switch in the differentiation potential of satellite cells to an adipogenic phenotype could be partly responsible for intramyocellular lipid deposition and insulin resistance in type 2 diabetes, obesity and age-related sarcopenia, organe-selective modulation of the Wnt/β-catenin pathway could contribute to fight intramuscular fat depots and improve insulin sensitivity in these pathologies. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.