For example, MITF was shown to bind and transactivate the HIF1a promoter in mouse B16 melanoma cells [29], yet in our study HIF1a was inversely correlated with MITF expression, particularly in the invasive cell lines, suggesting de-regulated MITF and/or cAMP signalling in NZM cells, or that B16 cells may not be a good model of human metastatic melanoma. Here, MITF is linked to metastatic melanoma.