Thirty-five of the genes in our 96-gene invasion signature are known or predicted targets of MITF [18], and although experimentally confirmed MITF targets such as MLANA, RAB27A, and GPR143 corresponded closely with MITF expression in our data, some did not, suggesting a disconnect in MITF signalling for some MITF targets in certain melanomas. This evidence concerns the gene RAB27A and melanoma.