One of the Motif 2 cell lines, NZM04, showed relatively low levels of MITF targets (e.g. DCT, CDK2, BCL2, GPR143) despite having relatively higher MITF expression (Figure 1B, C), indicating that there are probably melanoma sub-types present within the broad Motif 1 and 2 classifications, and that not all cell lines with lower MITF have a Motif 1 expression profile. This evidence concerns the gene GPR143 and melanoma.