This situation would be similar to the role of NOD2 in Crohn's disease, in which wild type NOD2, also a member of the NLR family [40], inhibits TLR2 (toll-like receptor-2) activation by peptidoglycan, while mutated NOD2 fails to inhibit TLR2, leading to chronic inflammation in the bowel [41]. This evidence concerns the gene NOD2 and Crohn disease.