It has been suggested that that this feedback regulation of SREBP-2 is lacking in PCa, through the observation that treatment with sterols reduced SREBP-2 target gene expression, as well as low-density lipoprotein (LDL) uptake, in normal cells but not in PC-3 and DU145 PCa cells in vitro[9]. Here, SREBF2 is linked to posterior cortical atrophy.