SREBF2 and posterior cortical atrophy: We propose that this ‘regulatory gauge’ is higher in PC-3 cells (Fig. 4D), accounting for 1) PC-3 cells having higher basal SREBP-2 than LNCaP cells, 2) statins appearing to have little effect in PC-3 cells (relative to the basal condition), and 3) sterols reducing SREBP-2 activity in both PCa cell-lines.