Our preliminary data suggest that hepatitis B infection poses a substantial health threat in this community, so routine screening for anti-HBc is particularly important in Egyptian blood donation centers as an additional preventive measure for controlling transmission of HBV with its potential consequences particularly in immunocompromised hemodialysis patients, but confirmatory testing of HBV DNA must be done for positive anti-HBc hemodialysis patients to ensure active infection. This evidence concerns the gene KRT88P and hepatitis B virus infection.