Here, the myocardial transcriptional changes, hallmarks of AS, seem to be under the influence of circulating TGF-β1, as suggested by the direct correlation between preoperative plasma levels of TGF-β1 and LV expression of genes encoding ECM elements (collagens I and III and fibronectin) as well as sarcomeric elements (β-myosin heavy chain and myosin light chain-2). This evidence concerns the gene MYL2 and aortic stenosis.