In present study of acute pancreatitis also, there was a significant increase of ICAM-1, VCAM-1, E-selectin and P-selectin in mice pretreated with vehicle confirming their pro-inflammatory role, while pretreatment with NaHS 10 mg/kg caused significant reduction of pancreatic ICAM-1, VCAM-1, E-selectin and P-selectin as well as pulmonary ICAM-1, VCAM-1 and P-selectin (Fig. 5). The gene discussed is VCAM1; the disease is acute pancreatitis.