In our initial experiment when the mice were treated with different dosages of NaHS (5 mg/kg, 10 mg/kg and 15 mg/kg) 1 h before caerulein-induced acute pancreatitis, it was revealed that there was a dose dependent reduction of plasma amylase (Fig. 1), pancreatic inflammation as evidenced by pancreas MPO and histology (Fig. 2A and 2B) and pulmonary inflammation, as evidenced by lung MPO and histology (Fig. 3A and 2B) and a significant reduction of inflammation was seen only in mice pretreated with NaHS 10 mg/kg (Fig. 1, Fig. 2A and 2B iv, Fig. 3A and 3B iv). This evidence concerns the gene MPO and acute pancreatitis.