Following our group's original suggestion that a function of human CRP might be to safely scavenge potential autoantigens (4, 5), the reports of immunomodulatory effects of injections of human CRP and of transgenic expression of human CRP in murine models of SLE-like autoimmune disease and nephrotoxic nephritis were very intriguing (6–9). This evidence concerns the gene CRP and systemic lupus erythematosus.