The strongest signal of association was observed for variants in TCF7L2 (lead SNP rs4506565), with more convincing evidence obtained from the multinomial regression analysis (P = 4.0 × 10−14) than the logistic regression analysis of all T2D cases, combined (P = 3.0 × 10−12). This evidence concerns the gene TCF7L2 and type 2 diabetes mellitus.