In the present study, we determined the genotypes of two functional polymorphisms, MMP1 (1G/2G, -1607) and MMP3 (5A/6A, -1171), in healthy individuals and in patients with XFS and XFS/+G, and for the allele contrast we found a trend for association only between the MMP1 variant and XFS without glaucoma. This evidence concerns the gene MMP1 and glaucoma.