In this study, our aims were (i) to evaluate the antiproliferative activity of Cin, Ca and Cal in human hepatoma Hep G2 (CD95-positive) cells; (ii) to investigate the role of p53, Bcl-2 family proteins (Bax and Bcl-XL) and PARP in Cin-mediated apoptosis; and (iii) to study the effects of PFTα on p53 and Bcl-2 family proteins, as well as PARP cleavage in Hep G2 cells. The gene discussed is TP53; the disease is hepatocellular carcinoma.