In the group of children with Crohn's disease, 15 patients (39.5%) were carriers of at least one mutation of CARD15 gene; among them the most frequent was R702W mutation in 7 children (18.4%), L1007fs mutation in 6 children (15.8%), the least frequent was G908R mutation in 3 children (7.9%). Here, NOD2 is linked to Crohn disease.