EGFR and ovarian carcinoma: In one study where signaling proteins downstream of EGFR induced ovarian cancer, transgenic mice harboring exogenously controllable (“floxed”) expression of phosphatase and tensin homolog (PTEN) and mutated K-RAS genes were induced to gain oncogenic K-RAS and lose tumor suppressing PTEN expression in the ovaries via injection of an adenovirus-Cre recombinase vector into the infundibulum [67].