EGF and ovarian adenocarcinoma: EGF can also affect pathways associated with angiogenesis, as EGF stimulation of the human ovarian adenocarcinoma cell line OVCAR-3 leads to increased H2O2 levels, which in turn activates the AKT-P70S6K pathway and increases vascular endothelial growth factor transcription through hypoxia-inducible factor-1α expression [47].