EGFR and ovarian cancer: Also, while EGFR in ovarian cancers has been screened for potential activating events via presence of EGFRvIII [38, 39] or activating mutations in the kinase domain [6, 35–37], it is possible that ovarian cancers might have a yet unidentified EGFR activating “hot spot.” Screening and analysis of full-length EGFR will be required to determine if this is the case.