While none of these methods have directly examined the role of EGFR aberrations in ovarian cancer, some of these methods have been applied to other tumor models (e.g., glioma [65], lung adenocarcinoma [66]) in which EGFR perturbations (activating mutations) have been studied, indicating that EGFR-mediated tumor development can be successfully developed in transgenic mice. Here, EGFR is linked to central nervous system cancer.