CXCL8 and Cachexia: There were significant differences in the genotype frequencies of the IL-8 gene +781 C/T polymorphism between patients with cachexia and without (Table 4) (P = .009), and a significantly increased frequency of +781 T allele was noted in patients with cachexia (OR = 2.247, 95% CI: 1.351–3.737, P = .002).