Chronic infection with malaria parasites has been associated with immunosuppressive responses to the parasite and to unrelated antigens [14].In animal models of malaria, the release of interferon gamma (IFN-γ) has been shown to mediate protection when secreted by Plasmodium specific CD8 [15] or CD4 T-cells [16], [17]. The gene discussed is IFNG; the disease is malaria.