GSTM1 and hypertensive disorder: In combination with congenic strain construction in the SP.WKYGla2a and SP.WKYGla2c* strains, genome-wide microarray expression profiling identified glutathione S-transferase mu type 1 (Gstm1) as a positional candidate gene for spontaneous hypertension [40–42], and endothelial differentiation gene 1 (Edg1) and vascular cell adhesion molecule 1 (Vcam1) for salt sensitivity [43].