We refer to recent reviews on the genetics of the renin–angiotensin–aldosterone system [63–65], G-proteins [66], adducin [67], and oxidative stress [68,69] in hypertension, but will discuss the association of the aldosterone synthase gene (CYP11B2) with hypertension as an exemplar. The gene discussed is CYP11B2; the disease is Hypertension.