Although further functional studies will certainly be required to better understand the exact role of B7-H3 in pancreatic cancer, our data suggest that B7-H3 might be involved in the induction of a specific antitumor immune response and that treatment with B7-H3 (e.g. by gene transfer) might represent a promising approach to improve the outcome of pancreatic cancer patients. This evidence concerns the gene CD276 and familial pancreatic carcinoma.