To assess the effect of the Th1 and Th2 cytokines IFN-γ and IL-4 on B7-H3 expression by cultured pancreatic cancer cells, cells (representative pancreatic cancer cell lines Panc-1 and SU86.86) were incubated with recombinant IFN-γ and IL-4 for 24 and 48 hours. This evidence concerns the gene IFNG and familial pancreatic carcinoma.