We are first to report the (1) decrease in phagocytosis of mycobacteria by PKC-α deficient macrophages (2) knockdown of PKC-α results in increased survival of mycobacteria within macrophages (3) PknG from Mtb selectively downregulates PKC-α during infection (4) Expression of PknG in MS reduces the phagocytosis by macrophages and (5) the downregulation of PKC-α is mainly due to the proteolytic degradation by PknG. This evidence concerns the gene PRKCA and myeloid sarcoma.