PRKCA and infection: To know whether infection of macrophages with BCG and Ra also results in the downregulation of PKC-α, we infected macrophages with mycobacteria and observed that infection of THP-1 cells with BCG and Ra also decreased the expression (2.5 and 5.7 fold respectively) as well as the phosphorylation of PKC-α by 2.5 and 5 fold respectively (Fig. 1A and 1B).