For example, ZnT3 gene knock-out in an AD transgenic mouse model (Tg2576) resulted in reduced plaque load and cerebral amyloid angiopathy [15,16], and a study of another AD transgenic mouse model (APPswe/PS1dE9) detected increased ZnT3 protein levels in comparison to wild-type littermates [27]. Here, SLC30A3 is linked to Alzheimer disease.