Pooling of all AD patients (Braak 4, 5 and 6), for comparison with all controls (Braak 1 and 2), showed that NSE expression was significantly decreased in superior frontal gyrus in AD (44% reduction), while the decreases in NSE mRNA levels in superior parietal gyrus (27% reduction), superior occipital gyrus (17% reduction) and medial temporal gyrus (9% reduction) did not reach statistical significance. The gene discussed is ENO2; the disease is Alzheimer disease.