Second, virulence factors of H. pylori such as cagA gene and H. pylori-induced immune/inflammatory factors were not detected in the present study, which does not allow further speculation of the mechanisms how H. pylori infection may contribute to the initiation and development of coronary atherosclerosis.In conclusion, there is a significantly association between H. pylori seropositivity and decreased blood HDL-c levels. The gene discussed is S100A8; the disease is coronary atherosclerosis.