Early trauma has been associated with long-lasting abnormalities in several biological systems that have also directly been implicated in the pathophysiology of major depression, including the serotonergic (5HT) and the corticotropin-releasing factor (CRF) systems [Arborelius et al., 1999; Heim and Nemeroff, 2002; Edwards et al., 2003; Nemeroff, 2004]. Here, CRH is linked to major depressive disorder.