ADIPOQ and type 2 diabetes mellitus: Their levels of plasma adiponectin are significantly depressed.42 Women with prior gestational diabetes mellitus (pGDM) are at increased risk of development of T2D, and they also had lower plasma adiponectin concentrations compared with unaffected women.43,44 Evidence has also indicated that plasma adiponectin levels independently correlate β-cell function in late pregnacy of diabetic patients.