Interestingly, +276(G/T), as a putative functional SNP (pf-SNP), is found to be associated with plasma adiponectin levels in T2D,74 T1D91 and also in nonalcoholic steatohepatitis (NASH).92 The promoter polymorphisms, including −11426A/G, −11377C/G and −11391G/A, are also found to be associated with are associated with circulating adiponectin levels in diabetes and obesity. This evidence concerns the gene ADIPOQ and metabolic dysfunction-associated steatohepatitis.