ADIPOQ and obesity due to melanocortin 4 receptor deficiency: There are two independent association signals, which are represented in these two LD blocks.73 The SNPs i.e. +45T/G and +276G/T in the AdipoQ gene are the common polymorphisms associated with T2D, obesity and insulin resistance.74–81 A haplotype defined by these two SNPs is found to be strongly associated with many components of insulin resistance syndrome.73,82 However, association of +45T/G and +276G/T polymorphisms with T2D is not seen in French and Swedish Caucasians.