There is no significant gender difference of plasma adiponectin levels in gender for newborn infants.28–31 However, plasma adiponectin levels were inversely correlated with obesity and insulin resistance in boys and girls.32 Adiponectin values is found to be decreased in the children whose body mass index (BMI) increased.33 Sex differences in adiponectin are dependent on both puberty stage and adiposity in adolescents.34 In adult, adiponectin expression from adipose tissue is higher in lean subjects and women, and is associated with higher degrees of insulin sensitivity.35 Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.