The linkage disequilibrium (LD) of the AdipoQ gene is moderate, but there are two small LD blocks, one including SNPs in the promoter region and another one spanning the boundary of exon 2-intron 2.72 In the recent 8 years, a number of genetic association studies for the AdipoQ gene polymorphisms in T2D, obesity and other metabolic disorders have been reported, and the references are selected in this review. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.