Patients with major depression has been found to have elevated corticotrophin releasing factor (CRF) concentrations in cerebrospinal fluid (CSF) [12], blunting of adrenocorticotropic hormone (ACTH) response to CRF administration, nonsuppression of cortisol secretion following dexamethasone administration, and hypercortisolemia [13]. Here, POMC is linked to adrenal gland hyperfunction.