For example, the newly identified IDH1 mutation was often coincidental with TP53 mutations (83% of cases compared with 27% in patients with wild-type IDH1) and negatively correlated with the presence of PTEN, RB1, EGFR or NF1 mutations (0% of cases compared with 60% in patients with wild-type IDH1), suggesting fundamentally different cancers at the molecular level. Here, IDH1 is linked to cancer.