CRP and age-related macular degeneration: Recent studies provide mounting evidence that inflammation is pivotal in the pathogenesis of AMD.[5] Drusen contains complement components and complement regulators, immunoglobulins, and cells which may represent antigen-presenting cells (APC) and macrophages.[6] The possibility of systemic immune alongside local ocular (either structural or immunregulatory) dysregulation is compounded by studies where firstly significant associations were noted between elevated serum C-reactive protein (CRP) levels and polypoidal choroidal vasculopathy and neovascular AMD.[7]