The cumulative risks for CRC in females were lower compared to males, 57% for MLH1, 52% for MSH2 and 30% for MSH6 mutation carriers (Figure 3), with a significantly lower age related cumulative risk in MSH6 mutation carriers (p = 0.001) compared to MLH1 and MSH2 mutation carriers. This evidence concerns the gene MLH1 and colorectal carcinoma.