There were no significant differences in the age of onset of other LS-associated cancers between MLH1 (53 years; range 52-54 years), MSH2 (42 years; range 23-59 years) and MSH6 (50 years; range: 35-76) mutation carriers (MLH1 vs. MSH2, p = 0.41; MLH1 vs. MSH6, p = 0.76 and MSH2 vs. MSH6, p = 0.41). The gene discussed is MLH1; the disease is cancer.