MSH6 and colorectal carcinoma: The median age of CRC onset in males was significantly higher in MSH6 mutation carriers (48 years; range 32-84 years) compared to MSH2 mutation carriers (43 years; range 20-51 years, p = 0.03), but not significantly higher compared to MLH1 mutation carriers (45 years; range 33-63 years, p = 0.07) (Table 2).