For female mutation carriers, no significant differences in the median age of CRC onset were found when comparing MSH6 (53 years; range 34-61 years) with MLH1 (50 years; range 25-79 years, p = 0.88) and MSH2 (44 years; range 29-82 years, p = 0.28). This evidence concerns the gene MLH1 and colorectal carcinoma.