CDH1 and inflammatory breast carcinoma: In MARY-X, disruption of the intact axis by Ca++ depletion, E-cadherin antibody, glycan modification of MUC1 and trypsin proteolysis results in the total dissolution of the in vitro spheroids followed by apoptosis, suggesting that over-expressed E-cadherin/α, β-catenin axis plays an important role in the survival of highly metastatic IBC [20-22].