By identifying genes with the highest expression in a population of canine osteosarcoma and marginal expression in a population of human osteosarcoma patients, two of four "dog-like" genes, IL8 and SLC1A3 (IL-8, p = 0.0201; SLC1A3, p = 0.0264), were defined that were negatively associated with survival in a distinct human osteosarcoma data set. The gene discussed is SLC1A3; the disease is osteosarcoma.