Evaluation of the dog-like genes in a distinct population of human osteosarcoma patients, which were linked to clinical outcome, confirmed that two genes (IL-8, interleukin-8, and SLC1A3, solute carrier family 1 (glial high affinity glutamate transporter)) were potentially associated with a more aggressive clinical course in human patients. Here, SLC1A3 is linked to osteosarcoma.