In future interventional studies, in addition to liver enzymes, high-sensitivity C-reactive protein, gamma-glutamyl transpeptidase, uric acid, vitamin D, adiponectin, ghrelin level, insulin levels, insulin resistance and the oral glucose tolerance test could be the integral part of the evaluation of patients with NAFLD to further clarify the relationships among different biologic factors and metabolic syndrome. Here, ADIPOQ is linked to metabolic syndrome.