Although the protective effect of lipid-lowering medication on CVD and stroke risk is well-established [4,9,10], data regarding the relative importance of the various lipid parameters, total cholesterol (T-CHOL), LDL, HDL, non-HDL cholesterol, triglycerides (TG), lipoprotein a (Lp(a)), apolipoprotein (Apo) B and A-I, to CVD and stroke risk is inconclusive. The gene discussed is APOB; the disease is Stroke.