The CUL-5 transcript encodes a component of the E3 ubiquitin ligase which is a part of the proteasomal complex involved in attachment of ubiquitin molecules to targeted proteins and has been associated with breast tumorigenesis [26]; interestingly, this gene is found in a region of chromosome 11q we have shown to be commonly deleted in neuroblastoma and associated with poor outcome [28]. This evidence concerns the gene CUL5 and neuroblastoma.