MAPT and early-onset autosomal dominant Alzheimer disease: While not supporting a pathogenetic similarity of ADC/HIVE and Alzheimer's disease or an Alzheimer's disease-like CSF biomarker pattern in ADC/HIVE, these results do suggest that amyloid and tau metabolism are perturbed in HIV-related brain injury, and that combined measurement of CSF biomarkers may have clinical application in certain settings.