In the 53 ESCC cases with high EZH2 expression, an average of 55.0% of the ESCC cells stained positively with H3K27me3 antibody, a percentage of cancer cells that was significantly larger than that (43.3%) in the remaining 45 cancers with a low expression of EZH2 (P = 0.036, Fig. 1G). The gene discussed is EZH2; the disease is cancer.