IL6 and systemic inflammatory response syndrome: Indeed, a closer look suggests that the primary elevated inflammatory cytokine is IL-6, which we have suggested through computational studies may be indicative of a positive feedback loop of inflammation→tissue damage/dysfunction→inflammation [15] Interleukin-6 is arguably the best biomarker of outcome of trauma patients with Systemic Inflammatory Response Syndrome, sepsis, and Multiple Organ Failure [13], [25].