MDM2 was rarely reported to be a prognostic factor in HCC, but was often reported in the maxillary sinus squamous cell carcinoma [33], in Egyptian esophageal carcinoma [34], in breast carcinoma [35], prostate adenocarcinoma [36], gastric cancer [37,38], and epithelial ovarian cancer [39,40]. Here, MDM2 is linked to squamous cell carcinoma.