Univariate analysis showed that the following factors were significantly related to postoperative survival: tumor depth, lymph node metastasis, distant metastasis, stage, lymphatic invasion, venous invasion, Twist expression, E-cadherin expression and the combination of Twsit and E-cadherin expression (P < 0.05). Here, CDH1 is linked to metastatic malignant neoplasm in the lymph nodes.