The transcription factors as biomarkers (PBX1, EP300, STAT6, SREBF1, NFKB1, STAT3, EGR1, E2F3, NR2F2) see Additional file 3 are only involved in the cancer networks and those genes are annotated in cancer-related transcription regulatory factors (p-value 1.18E-9). Here, E2F3 is linked to cancer.