The results, showing a statistically significant interaction of the p53 Pro-variant and the GG genotype of MDM2 SNP309, are in line with our a priori biologically-supported hypothesis, which is, the role of enhanced DNA repair function of the Pro-variant, combined with increased expression of the Mdm2 protein, and thus overall attenuation of the p53 pathway in the tumor cells. This evidence concerns the gene TP53 and neoplasm.