MAPT and neuroblastoma: Use of HEK 293 cells was not expected to limit the hits obtained from our screens, given that spontaneous exon skipping of minigene constructs could occur in this cell line, and that an analogous screen monitoring splicing of a microtubule-associated protein tau (MAPT) construct was recently performed in HEK 293 cells and identified drugs capable of functioning on endogenous MAPT in SHSY-5Y neuroblastoma cells [36].