Specifically, among CpGs hypomethylated in cancer cases, there was enrichment of genes known to be upregulated in granulocytes (P = 2×10−5, Table 1), while CpGs hypermethylated in cancer were enriched for genes known to be upregulated in T-cell lymphocytes (CD4+ P = 0.002, CD8+ P = 0.01, Table 1, Table S4), consistent with reports of a higher granulocyte/lymphocyte ratio in the blood of cancer cases compared to healthy controls [26], [29]. Here, CD4 is linked to cancer.