PTPN22, SLC22A4, HLA-DRB1, IL6, PADI4, TRAF1, NFkBIL1, C5, and RUNX1 may play interactive roles for RA, especially PTPN22 and SLC22A4, which are related to the reaction of antigen for RA. The gene discussed is RUNX1; the disease is rheumatoid arthritis.