TCF7L2 and type 2 diabetes mellitus: These synthetic approaches allowed for successful detection of  CDKN2B and TCF7L2 interacting effect for T2D risk and CDKN2B and  JAZF1 interacting effect on TG/HDL ratio increase over time among  T2D families in the FHS. These interacting effects were consistent  in conferring risk of T2D or progressive insulin resistance with  modest effect sizes.