Interaction between CDKN2B rs10811661 and TCF7L2 rs4506565 variants were significant (β = 1.6667, p = 0.0002, 0.0341, and 0.0012 for main and interacting effects), and it was associated with high slope values, which may be expressed as an increase in insulin resistance across ages. Here, CDKN2B is linked to Insulin resistance.