Studies conducted in adults using 8 to 10 metabolic measures (fasting insulin, fasting glucose, post-challenge insulin, post-challenge glucose, body mass index (BMI), waist circumference or waist-to-hip ratio (WHR), high density lipoprotein-cholesterol (HDL), triglycerides (TG), systolic blood pressure (SBP), diastolic blood pressure (DBP)) have shown that the MetSyn is best described, statistically, as a unifying, second-order factor defined by four first-order factors (Insulin Resistance, Obesity, Hypertension, Lipids) [8-10]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.