TRAF1 and rheumatoid arthritis: Examining the two-sided alternative hypothesis shows that SNPs rs12380341 (p = 9.7 × 10-11) and rs872863 (p = 1.7 × 10-15), along with six SNPs across the TRAF1-C5 locus, rs1953126, rs10985073, rs881375, rs3761847, rs10760130, and rs2900180 (p~1 × 10-7), are significantly associated with anti-cyclic citrullinated peptide-positive rheumatoid arthritis.