Despite the rarity of minor allele frequency for the above two SNPs, PAPPA gene, a metalloproteinase, is reported to regulate the human atherosclerotic plaque [14]; FBN3 (Fibrilin 3) is reported to contribute in the polycystic ovary syndrome, which is associated with obesity [15]. This evidence concerns the gene FBN3 and obesity due to melanocortin 4 receptor deficiency.