We observed that acute administration of clinically relevant levels of latrepirdine stimulated extracellular accumulation of Aβ in three extracellular systems, namely: (1) the conditioned media of cultured human Swedish mutant (Swe)APP-transfected mouse neuroblastoma cells, (2) the releasate of cortical synaptoneurosomes isolated from TgCRND8 (Swe/Indiana APP) transgenic mice, and (3) the interstitial fluid from the brains of freely moving Tg2576 SweAPP transgenic mice. This evidence concerns the gene APP and neuroblastoma.